VW is expected to launch an electric vehicle based on the I.D. concept, the VW Neo, next year. It is expected to be the Volkswagen Group’s first mass-market ‘affordable’ electric car.The vehicle is expected to be offered in 3 different battery pack configurations based on the MEB platform and will start at around $30,000, according to a new report. more… Source: Charge Forward
Source: Electric Vehicle News Mark October 8 on your calendarsThere’s a charm to riding on a Vespa—make the road you’re on an Italian one and you become part of the mother of all clichés. From the quirky manual transmission—all the clutching and shifting happens with the left hand—to the premixed miscela, a cocktail of oil and gas, the Vespa has always been a bit of a living dinosaur. Vespas aren’t quite like that anymore, though. They now feature a fancy CVT and the oil doesn’t have to be mixed in with the gas. Now the Vespa is taking yet another step into modern days with the introduction of its electric variation for a clash of modern and old school.The Vespa Elettrica is just around the corner. Potential buyers will be able to reserve theirs starting October 8 as indicated on the Piaggio website. In the U.S., the calendars will have to turn over to 2019 before this variation of the Vespa hits the showrooms.Piaggio has worked hard to make its old lady Vespa extra smart and connected. Not only will it receive the company’s first ride-to-rider connectivity technology, but Piaggio expects to be able to eventually make the Vespa able to communicate with other artificial intelligence systems, including the Gita’s, Piaggio’s little sidekick, bag-carrying robot. The future Vespa will provide the rider with a flight of information it will harvest from other connected vehicles and infrastructures.Until then, we get a first peek at what Piaggio has in mind for the future with the 2019 Vespa Elettrica. Performance numbers should compare to those of the 50cc, except for torque: the 2 kW electric motor will produce a healthy 148 lb-ft of torque. The lithium battery is rated for a decent 60 miles range and will take up to 4 hours to charge. The technology will, however, come at a price. Though no official number has been announced yet, Piaggio confirms that the Vespa Elettrica will rub shoulders with the high-end, more expensive models in the family.Source: Rideapart Author Liberty Access TechnologiesPosted on October 4, 2018Categories Electric Vehicle News
Eco-friendly estate now gets clever aerodynamic bumper and new range-topping trim level.Kia has updated its Optima Sportswagon plug-in hybrid estate car for 2019 with a host of equipment upgrades.More Optima News Author Liberty Access TechnologiesPosted on January 8, 2019Categories Electric Vehicle News Quiet EV Newcomer, The Kia Optima Plug-In Hybrid Taken Out For A Spin – Video Kia Optima Sportwagon PHEV Review Check Out The New Kia Optima Plug-In Hybrid – Review Video Source: Electric Vehicle News The eco-friendly family wagon has been given aesthetic tweaks at the front end, as well as a new range-topping trim level.As before, the car uses a 2-litre petrol engine and an electric motor to provide propulsion. Together, the two units produce 202 bhp, resulting in a 0-60 mph sprint of 9.4 seconds and a top speed of 119 mph.On electrical power alone, the car can travel up to 33 miles before the battery runs flat – a figure that enables the Optima to return up to 188 mpg on the official fuel economy test.For company car consumers, the vehicle emits a mere 33 g of carbon dioxide per 100 kilometres travelled, which means it qualifies for a benefit-in-kind tax rate of 13 percent.To help with this cause, the Optima has been given a redesigned front end with a flap in the grille opens and closes to manage the airflow. There’s also a new lower bumper with a set of LED daytime running lights, and new alloy wheels. The combination is designed to make the car cleave through the air more cleanly, improving efficiency and emissions.Kia has changed the car’s suspension, too, to compensate for the battery and electrical systems. The set-up has been tuned to make the car ride and handle like its conventionally powered brother, while bigger rear brakes have also been fitted, helping to slow down the car’s extra mass.In the cabin, the South Korean manufacturer has upped the ante with the Apple CarPlay and Android Auto smartphone connectivity systems, which are now standard on all models.From this year, the car will be offered to UK customers in a choice of two trim levels, with the entry-level PHEV model joined by the more generously equipped PHEV Plus variant.The basic PHEV costs £34,995, and for that money you get 17-inch alloy wheels, LED headlights and an eight-inch touchscreen satellite navigation and infotainment system. Part-leather seats are also included as standard, along with a Harman/Kardon premium sound system, a reversing camera and two-zone climate control.Upgrading to the Plus model brings the price tag up to £38,995, but buys you full leather upholstery, a panoramic sunroof and an electrically operated automatic tailgate, plus a 360-degree maneuvering camera and a wireless phone charger.
With the increased availability of on-demand food delivery services, food couriers are flooding the streets of cities worldwide.While many of these delivery riders use gas-powered scooters, Deliveroo is working to transition them towards more eco-friendly electric mopeds instead. more…The post Deliveroo is now renting electric mopeds to delivery riders by the hour appeared first on Electrek. Source: Charge Forward
Source: Electric Vehicle News On the same day, the iEVA60 officially hit the market with two variants, priced between RMB179,500 and RMB189,500.At the launching ceremony, JAC Motors announced the prices of six NEV models applicable to transition period for new NEV subsidy policy, including the iEV7S, the iEVA50, the iEVA60, the iEV7L, the iEV6E Upgrade and the iEV6E Sports. The price with green-car subsidy of the iEV6E Upgrade is as low as RMB59,500.The automaker is about to set the iEVS4 all-electric SUV into the market at the impending Auto Shanghai 2019. The presale of the new model has already started on January 28 with prices ranging between RMB130,000 and RMB170,000 (after subsidy). The iEVS4 reportedly boasts a combined driving range of 420km, outnumbering that of the BYD Yuan EV535.JAC Motors reported on April 9 that its sales in March fell 17.51% over a year ago to 44,317 units, among which the all-electric passenger vehicle (PV)’s sales amounted to 6,616 units, showing a year-on-year jump of 31.5%. For the first quarter of the year, the carmaker saw the cumulative all-electric PV sales leaped 28.26% to 15,007 units.Source: Gasgoo GAC NIO To Launch New Battery-Electric Brand XPENG Teases New P7 Electric Coupe Ahead Of Auto Shanghai Debut Author Liberty Access TechnologiesPosted on April 14, 2019Categories Electric Vehicle News Ford To Launch 10 New Electrified Vehicles In China In 3 Years More and more EVs from China.JAC Motors released its new product planning on April 9, saying it plans to launched three all-new models—the A432, the S432 and S811, and seven upgraded models from 2019 to 2021.Of that, NEV models are scheduled to be rolled out include the iEVA60, the iEVA432, the iEVS4, the X811 (compact SUV) and a brand-new A00-segment sedan.More China News
Rapide E is the first all-electric Aston MartinSource: Electric Vehicle News
Share on Facebook Sign up to the Spin – our weekly cricket round-up Lawrence Booth Share on Facebook Share on Twitter Hampshire Share on Twitter Support The Guardian Hampshire Fletcher prepares to reunite with Pietersen in Hampshire role Share via Email … we have a small favour to ask. The Guardian will engage with the most critical issues of our time – from the escalating climate catastrophe to widespread inequality to the influence of big tech on our lives. At a time when factual information is a necessity, we believe that each of us, around the world, deserves access to accurate reporting with integrity at its heart.More people are reading and supporting The Guardian’s independent, investigative journalism than ever before. And unlike many news organisations, we have chosen an approach that allows us to keep our journalism accessible to all, regardless of where they live or what they can afford. But we need your ongoing support to keep working as we do.Our editorial independence means we set our own agenda and voice our own opinions. Guardian journalism is free from commercial and political bias and not influenced by billionaire owners or shareholders. This means we can give a voice to those less heard, explore where others turn away, and rigorously challenge those in power.We need your support to keep delivering quality journalism, to maintain our openness and to protect our precious independence. Every reader contribution, big or small, is so valuable. Support The Guardian from as little as $1 – and it only takes a minute. Thank you. Share via Email “It would be similar to what I did at Western Province,” Fletcher said. “I appreciate [Hampshire’s chairman] Rod Bransgrove’s approach and why they’ve gone with Giles White as coach, and their proposition to me was of real interest. They want someone to analyse the team structure and advise on where the side is going right and wrong, but I would also expect to do some hands-on coaching.”The details of the arrangement are still being finalised but, if everything goes to plan, the 60-year-old is expected to begin in April. It is inconceivable that Hampshire’s batsmen – including Pietersen – would not want to exploit one of the finest technical minds in the world game. “I’ve worked well with Kevin Pietersen in the past,” Fletcher added. “And maybe I’ll still do some full-time coaching along the line.”Suggestions that Fletcher will be joined on the south coast by Michael Vaughan, Pietersen’s predecessor as England’s Test captain, remain speculation. But Vaughan, currently at Yorkshire, would be forgiven for being tempted: Fletcher’s impact has been felt at every team he has been involved with. Western Province won South Africa’s first-class domestic tournament, the Castle Cup, under his guidance in 1995-96, and in 1997, his first season at Glamorgan, he helped them lift their first County Championship for 28 years.England appointed him as coach in 1999 and within a few years he had lifted them from bottom of the unofficial world rankings to second behind Australia.Bransgrove, moreover, believes Fletcher still has the capabilities that helped England win the Ashes three years ago.”In Giles White and Tony Middleton [Hampshire’s academy director] we have two excellent young coaches and managers of great potential,” he said… “and both are looking forward to the possibility of working with Duncan next season. Giles did a superb job as caretaker manager during the last couple of months of the season and the team has responded positively to his style and commitment.” Read more Share on WhatsApp Kevin Pietersen England cricket team Duncan Fletcher and Kevin Pietersen may soon be reuniting at Hampshire. Photograph: Mark Nolan/Getty Images Share on Messenger England’s 2005 Ashes-winning coach, Duncan Fletcher, is set to resume his working relationship with Kevin Pietersen by taking on a consultancy role at Hampshire from the start of next season.Fletcher will be given the task of overseeing the cricketing set-up at the county, who are also believed to have tried to lure back their former captain Shane Warne as bowling coach. However, Giles White will be the first-team manager. The former Hampshire leg-spinner presided over the club’s rise from the lower reaches of the First Division to third place following the departure of Paul Terry in August. Cricket Share on LinkedIn Topics Since you’re here… County Championship 2003 Division One Shares00 Mon 6 Oct 2008 19.01 EDT Share on Pinterest First published on Mon 6 Oct 2008 19.01 EDT Reuse this content
Learning a new topic or elevating your knowledge and practical skills in a topic is not just for formal students in formal educational settings. Professionals in the workplace can also benefit from a “back to school” experience.For professionals in the FCPA space – or wishing to join the FCPA space – the FCPA Institute serves this objective and the next FCPA Institute will take place in Seattle on August 13-14.At a typical FCPA conference, 40-50 individuals bombard you with information during various panels. Just introducing these countless individuals takes over one hour in the aggregate. Moreover, the 3 p.m. panelists were likely not present for the 10 a.m. panel, thus information is presented in a disjointed and largely repetitive fashion.The FCPA Institute is different than a typical FCPA conference. At the FCPA Institute, information is presented in an integrated and cohesive manner by an expert instructor with FCPA practice and teaching experience.Moreover, the FCPA Institute promotes active learning by participants through issue-spotting video exercises, skills exercises, small-group discussions, and the sharing of real-world practices and experiences. To best facilitate the unique learning experience that the FCPA Institute represents, attendance at each FCPA Institute is capped at 25 participants.In short, the FCPA Institute elevates the FCPA learning experience for a diverse group of professionals and is offered as a refreshing and cost-effective alternative to a typical FCPA conference. The goal of the FCPA Institute is simple: to develop and enhance fundamental skills relevant to the FCPA, FCPA enforcement, and FCPA compliance best practices in a stimulating and professional environment with a focus on learning.The FCPA Institute presents the FCPA not merely as a legal issue, but also as a business, finance, accounting, and auditing issue. The FCPA Institute is thus ideal for a diverse group of professionals such as in-house and outside counsel; compliance professionals; finance, accounting, and auditing professionals; and others seeking sophisticated knowledge and enhanced skills relevant to the FCPA.Set forth below is what prior FCPA Institute “graduates” have said about their experience.“Unlike other FCPA conferences where one leaves with a spinning head and unanswered questions, I left the FCPA Institute with a firm understanding of the nuts and bolts of the FCPA, the ability to spot issues, and knowledge of where resources can be found that offer guidance in resolving an issue. The limited class size of the FCPA Institute ensured that all questions were answered and the interactive discussion among other compliance professionals was fantastic.” (Rob Foster, In-House Counsel, Oil and Gas Company)“The FCPA Institute was one of the best professional development investments of time and money that I have made since law school. The combination of black letter law and practical insight was invaluable. I would highly recommend the FCPA Institute to any professional who has compliance, ethics, legal or international business responsibilities.” (Norm Keith, Partner, Fasken Martineau, Toronto).“The FCPA Institute is very different than other FCPA conferences I have attended. It was interactive, engaging, thought-provoking and at the completion of the Institute I left feeling like I had really learned something new and useful for my job. The FCPA Institute is a must-attend for all compliance folks (in-house or external).” (Robert Wieck, CPA, CIA, CFE, Forensic Audit Senior Manager, Oracle Corporation)“The FCPA Institute is a top-flight conference that offers an insightful, comprehensive review of the FCPA enforcement landscape. Professor Koehler’s focus on developing practical skills in an intimate setting really sets it apart from other FCPA conferences. One of the best features of the FCPA Institute is its diversity of participants and the ability to learn alongside in-house counsel, company executives and finance professionals. (Blair Albom, Associate, Debevoise & Plimpton)“The FCPA Institute was a professionally enriching experience and substantially increased my understanding of the FCPA and its enforcement. Professor Koehler’s extensive insight and practical experience lends a unique view to analyzing enforcement actions and learning compliance best practices. I highly recommend the FCPA Institute to practitioners from all career stages.” (Sherbir Panag, MZM Legal, Mumbia, India)“The FCPA Institute provided an in-depth look into the various forces that have shaped, and that are shaping, FCPA enforcement. The diverse group of participants provided unique insight into how, at a practical level, various professionals evaluate risk and deal with FCPA issues on a day-to-day basis. The small group setting, the interactive nature of the event, and the skills assessment test all set the FCPA Institute apart from other FCPA conferences or panel-based events.” (John Turlais, Senior Counsel, Foley & Lardner)FCPA Institute participants not only gain knowledge, practical skills and peer insight, but can also elect to have their knowledge assessed to earn a certificate of completion upon passing a written assessment tool. In this way, successful completion of the FCPA Institute represents a value-added credential for professional development. In addition, attorneys who complete the FCPA Institute are eligible to receive Continuing Legal Education (“CLE”) credits, other professionals are eligible to receive Continuing Professional Education (“CPE”) credits and prior FCPA Institute participants have also received continuing education units from the Society of Corporate Compliance and Ethics.To learn more about the FCPA Institute and to register for the Seattle event, click here.
With the recent Petrobras enforcement action (see here for the prior post), there is lots of false and misleading information in the public domain regarding the actual FCPA settlement amount (that is the amount of money the DOJ and SEC will actually collect from the enforcement action). The Petrobras FCPA enforcement action is a net approximate $170 million action as clearly evidenced in the government’s documents as well as Petrobras’s own press release.This post highlights the top ten corporate FCPA settlements of all-time.It seems odd saying this, but the list (unlike other lists out there) only includes enforcement actions where the corporate defendant was charged with or found to be in violation of the FCPA’s provisions (not other laws). In addition, this list highlights net FCPA settlement amounts after consistently accounting for (unlike other lists out there) certain credits or deductions in several enforcement actions involving foreign companies.1. Siemens$800 million($450 million DOJ)($350 million SEC)20082. Alstom$772 million($772 million DOJ)20143. KBR/Halliburton $579 million($402 million DOJ)($177 million SEC)20094. Teva Phrama$519 million($283 million DOJ)($236 million SEC)20165. Telia$483 million($275 million DOJ)($208 million SEC)20176. Och-Ziff$412 million($213 million DOJ)($199 million SEC)20167. Total$398 million($245 million DOJ)($153 million SEC)20138. VimpelCom$397.5 million($230 million DOJ)($167.5 million SEC)20169. Alcoa$384 million($209 million DOJ)($175 million SEC)201410. Snamprogetti / ENI$365 million($240 million DOJ)($125 million SEC)2010
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TweetShare28ShareEmail28 SharesBeing told to turn the volume down on the tv and subsequently told to not sit so close to it.Figuring out the solution to the above dilemma was watching shows with the closed captions on.Having to take five extra minutes before swimming so I could get my custom ear plugs in.Knowing my whole day would be spent listening for beeps I could not hear and watching confused looks on adults faces upon the announcement that there would be hearing tests at school.Painful, occasionally bloody, landings in airplanes (especially when doing more than one flight in a journey).Always getting to class early to get a front row seat (better for hearing and lip reading).“Ohh” reactions from new doctors when they looked inside my ears.11 surgeries starting at the age of two.Always making sure I am positioned to the right of the person I am talking with.If you had asked me several weeks ago how being hard of hearing affected me I would have answered with the above list. Sure, some of those things are bothersome, but in the grand scheme of things I don’t have much to complain about. I have struggled with hearing and ear infections all of my conscious life. I have tried countless Western and Eastern remedies. By my early 20s I was burnt out; I stopped trying to fix it and just decided to “live with it”. Time went on, and for me life was normal.“Hey, do you want to review this product?”A one line email from my editor, Kavan. He knew I was hard of hearing (and had not found traditional hearing aids accessible). The attached email was from LifeEar CORE announcing their new disruption to the hearing aid industry: “The first hearing aid you can adjust yourself with a companion mobile app.” I jumped at the opportunity. I couldn’t believe this was finally happening. For years, I had wondered when the tech industry, which I live smack in the middle of in San Francisco, would tackle hearing-aids. The current options are prohibitively expensive and inaccessible. I have lived with hearing loss my whole life, severe enough for the past decade to warrant a hearing aid, and yet I did not know the depth of my desire to hear better until getting that email. I was positively giddy waiting for my LifeEar CORE to arrive.Getting hearing aids is not like getting glasses – there is no “Wow, trees have leaves from far away!” moment when you realize the whole world was a blur before you put them on. The change is much more subtle. At first, I heard new things that didn’t really add much to my quality of life – things like the fridge kicking on or paper rustling – but slowly, my brain adjusted (LifeEar’s instructions say this takes about three weeks) and began to tune out these periphery noises. I wore the hearing aid daily as recommended, and over the three week period the real benefits snuck up on me.I became so accustomed to my new hearing ability that one night at dinner when I could not hear what my companion was saying I became frustrated. I went into the app to change the setting to ‘Restaurant Mode’ to help with the background noise only to realize I had forgot to wear my LifeEar CORE. The level of frustration I felt trying to lip read while I was missing big swaths of the conversation showed me how much I had been missing for years. I realized how much frustration I had lived with every day. Was my apathy about parties and large dinners all introversion? Or was it frustration from not being able to hear well?If you asked me to make a new list of how hearing loss has affected me it would have only one item: isolation. I now know how much human connection being hard of hearing has cost me. (I want to name that I have deep reverence and respect for the connected and loving deaf community, my story is one of disconnection from the hearing world because my hearing was just good enough that I could pass largely undetected). I can’t help but wonder how many times someone told me something important and I smiled and nodded and they moved on rather than connecting, thinking I didn’t care. My hearing loss is largely invisible. I got by reading lips, guessing what people said and seeking out conditions where I could hear best.Thankfully, or maybe even subconsciously (on purpose), I have always done work that didn’t require perfect hearing. How many jobs would have been significantly harder for me? How much better could I have done in school had I been able to hear better? I cannot know what could have been. I can only hope for my future and the future of others. I am so grateful for what LifeEar CORE and others are doing to make hearing aids more accessible. I hope they continue to refine their product to bring even better solutions at even lower investments. How many others are out there living with hearing-loss and not knowing how different the world can be?Do you have a journey with hearing? Or know of another innovation in this space? Please share in the comments.Related PostsTweetShare28ShareEmail28 SharesTags: Hearing Loss Review
Jul 12 2018In a “proof of concept” study, scientists at Johns Hopkins Medicine say they have successfully delivered nano-size packets of genetic code called microRNAs to treat human brain tumors implanted in mice. The contents of the super-small containers were designed to target cancer stem cells, a kind of cellular “seed” that produces countless progeny and is a relentless barrier to ridding the brain of malignant cells.Results of their experiments were published online June 21 in Nano Letters.”Brain cancer is one of the most widely understood cancers in terms of its genetic makeup, but we have yet to develop a good treatment for it,” says John Laterra, M.D., Ph.D., professor of neurology, oncology and neuroscience at the Johns Hopkins University School of Medicine and a research scientist at the Kennedy Krieger Institute. “The resilience of cancer stem cells and the blood-brain barrier are major hurdles.”Blood that enters the brain is filtered through a series of vessels that act as a protective barrier. But this blood-brain barrier blocks molecular medicines that have the potential to revolutionize brain cancer therapy by targeting cancer stem cells, says Laterra.”To modernize brain tumor treatments, we need tools and methods that bypass the blood-brain barrier,” says Jordan Green, Ph.D., professor of biomedical engineering, ophthalmology, oncology, neurosurgery, materials science and engineering and chemical and biomolecular engineering at the Johns Hopkins University School of Medicine. “We need technology to safely and effectively deliver sensitive genetic medicines directly to tumors without damaging normal tissue.”A case in point, Green says, is glioblastoma, the form of brain cancer that Arizona Sen. John McCain is battling, which often requires repeated surgeries. Doctors remove the brain tumor tissue that they can see, but the malignancy often returns quickly, says Laterra. Most patients with glioblastoma live less than two years after diagnosis.Scientists have long suspected that cancer stem cells are at the root of what drives the return and spread of glioblastoma and other cancers. These stem cells give rise to other cancer cells and, if they evade the surgeon’s knife, can lead to an entirely new tumor.Laterra and Green, who are members of the Johns Hopkins Kimmel Cancer Center, designed a way to efficiently deliver super-tiny packets of microRNAs into established brain tumors. The microRNAs target brain cancer stem cells to halt their capacity to propagate and sustain tumor growth.The packets are made of biodegradable plastic similar to material used for surgical sutures and that degrades over time. They are 1,000 times smaller than the width of a human hair and typical of the size and shape of natural components that cells use to communicate. When cancer cells engulf the packets, they break apart and release their microRNA “payload” specifically where the microRNAs need to take action within the cancer cells.Related StoriesSugary drinks linked to cancer finds studyLiving with advanced breast cancerStudy reveals link between inflammatory diet and colorectal cancer riskEncased in the nanopacket are microRNAs that specifically bind to messenger RNAs linked to two genes: HMGA1 and DNMT, which function together to regulate gene expression programs in cells.When microRNAs bind to these messenger RNAs, they block their protein-making abilities and turn off programs that drive the cancer cells’ stemlike characteristics. Without their stemlike properties, the cancer cells are more differentiated, they lose their capacity to propagate tumors, and they may be more susceptible to radiation and drugs.For their experiments, the Johns Hopkins scientists implanted human glioblastoma cells into 18 mice. To mimic the clinical challenge of treating an existing tumor, the scientists waited 45 days before treating the animals to be sure they had well-formed tumors. Half of the animals received infusions of the nanopackets containing active microRNAs directly into their brain tumors, and the other half received nanopackets containing inactive microRNAs. To isolate the effect of the nanoparticles, the scientists used mice that were bred without immune system T-cells that target cancer cells.Five of the nine mice receiving inactive microRNAs (controls) died within two months, and the rest of the control mice died within 90 days. Three of the nine mice receiving active microRNAs lasted up to 80 days, and six lived to 133 days. Those six were humanely euthanized, and isolated mouse brains were examined for the presence of tumors.All of the control mice had large tumors in their brains when they died. Four of the mice that received active microRNAs and lived to 133 days had no tumors, and two had small ones.Green says that many genetic medicines are designed to target one gene. The type of nanoparticles the Johns Hopkins team used in this study can encapsulate multiple types of microRNAs to target multiple gene networks.When the brain cancer stem cells internalize the nanoparticle and transition to a non-stem-cell state, Laterra says, clinicians could exploit that condition, and give radiation or other drugs to kill the now-vulnerable cells.Green says scientific teams elsewhere are developing microRNA packets using lipid-based materials, and some standard chemotherapy is delivered in a fatty nanoparticle called a liposome.Green and Laterra say the nanoparticles in their study are able to permeate the entire tumor because rodent brains are small. Humans, with bigger brains, may need a pump and catheter to funnel nanoparticles throughout the brain.The Johns Hopkins team is working to scale up development of its nanoparticles and standardize their stability and quality before applying for permission to begin clinical trials on people.The research team has filed for a patent for part of the technology used in this research. Source:https://www.hopkinsmedicine.org/news/media/releases/scientists_create_nano_size_packets_of_genetic_code_aimed_at_brain_cancer_seed_cells?preview=true
Source:https://sahlgrenska.gu.se/english/research/news-events/news-article//new-findings-on-the-muscle-disease-laing-early-onset-distal-myopathy.cid1585875 Reviewed by Kate Anderton, B.Sc. (Editor)Sep 21 2018New avenues are now being opened for future treatment of Laing distal myopathy, a rare disorder that causes muscles in the feet, hands and elsewhere to atrophy. In a study published in the journal PNAS, researchers have identified an enzyme with a clear link to how the disease develops.”Now we know that the levels of enzyme activity are an important factor in how quickly the disease progresses. This may mean that the disease could be treated by artificially increasing the activity,” says Martin Dahl Halvarsson, PhD student in pathology at the Institute of Biomedicine at Sahlgrenska Academy, Sweden, and the study’s first author.The muscle disease Laing early-onset distal myopathy is caused by an inherited mutation in a muscle protein, myosin, that normally contributes to muscle contraction. The disease often appears at a young age, from age 5 up to about age 20.What happens with Laing is that muscle fibers, primarily in the legs, hands, hips, neck and shoulders, atrophy over a period of time. With reduced strength and mobility, patients experience impaired quality of life in the long term. How much and how quickly the disease develops varies greatly, however.Cawling and jumping abilityIn the current study led by Homa Tajsharghi, professor of biomedicine at the University of Skövde, researchers for the first time introduced the mutation for the disease in an entire organism. This was done through mutation of the gene for myosin in fruit flies. The team’s previous research has been based on cell culture experiments and experiments outside living organisms.Related StoriesImplanted device uses microcurrent to exercise heart muscle in cardiomyopathy patientsMarijuana isn’t a great choice for glaucoma treatment, says expertCommon cold virus strain could be a breakthrough in bladder cancer treatmentIn this study mutant flies were crossed with fruit flies that had acquired the property of overproducing a particular enzyme. This property is called Abba in fruit flies and MuRF in humans. This sends signals to the cell’s proteasome system to destroy the damaged muscle protein.The researchers then examined several aspects of both the larvae and the adult flies. They studied both how myosin and other proteins organize themselves over a period of time in diseased fruit flies. They also looked at the crawling patterns of the larvae and the adult flies’ ability to jump and climb.Enzyme that may provide reliefThe results show that Laing early-onset distal myopathy manifests itself similarly in fruit flies and humans and that the Abba enzyme constitutes a counterbalance to the mutation. Fruit flies with an overproduction of Abba are immune to the disease, provided they are heterozygotes, with one mutated and one normal gene.The homozygote flies, with double mutations, did not survive to adulthood. In humans, however, homozygotes have never been diagnosed. This might be because people cannot survive with double mutations.”We have treated diseased fruit flies that carry the same genetic change as patients with Laing distal myopathy,” says Homa Tajsharghi, corresponding author behind the study. “The flies were cured and recovered muscle strength and the ability to fly. Naturally there are differences between fruit flies and humans, and additional studies are needed.”
ShareTweetSharePinAmie John has graduated as a medical doctor from Albany Medical CollegeAmie Jemimah John originally from Colihaut in Dominica, has graduated with a Doctor of Medicine (MD) from Albany Medical College in New York.The title was conferred on John at the Commencement Exercises at Albany College which took place on Thursday May 23, 2019 at the Saratoga Performing Arts Center, Saratoga Springs, New York.Dr. John started her high school education at the Convent High School, then migrated to the United States when she was in third form. She completed her high school education at St. Barnabas High School in Bronx, New York. In 2013, she obtained a Bachelor of Arts in Biology from Lehman College in New York. In the fall of 2015, Amie started another leg of her journey at Albany Medical College. Her final year was a serious challenge when she lost her dad in June 2018, but she persevered.During the awards ceremony at the Commencement Exercises, Dr. John received “The Dr. George C. Carter Memorial Award”. This award is presented to the student who has made the most significant contribution in support of Underrepresented Medical Students at Albany Medical College.Dr. John will do her residency in Internal Medicine at the University of Massachusetts in Worcester, Massachusetts for the next 3 years.Dr. Amie John is the daughter of Jane Adonis who is from Colihaut and the late Augustus John from Salisbury.
ShareTweetSharePinSteve Hyacinth is a retired Chief Education OfficerRetired Chief Education Officer, Steve Hyacinth is the new chairman of the Integrity Commission of the Commonwealth of Dominica.Secretary to the Commission, Helen Ambo told Dominica News Online (DNO) that Hyacinth took his oath of office in April this year.Ambo also revealed that the other members of the Commission are former school principal Thomas Holmes who was nominated by the government and attorney, Cara Shillingford, who was the nominee of the opposition United Workers Party.The United Workers Party has not had a representative on the Integrity Commission since 2015 when parliament approved amendments to the IPO Act, without support from the the UWP parliamentary opposition .The amendments include a reduction in the size of the Commission, which enforces the Act, from seven to three members: one from the government, one from the opposition and a chairperson appointed by the President of Dominica upon recommendation from the Prime Minister after consultation with the Leader of the Opposition. The new Commission was also given the authority to decide whether it wanted to continue with matters that were before the old Commission.UWP political leader, Lennox Linton, was not opposed to reducing the Commission members from 7 to 5. He also said that his party did not have a problem with one Commissioner from each political party and to have the Prime Minister nominating the chairman in consultation with the Leader of the Opposition. However, he was strongly of the view that the professional bodies of law and finance (who were part of the old Commission) should continue to be represented on the Commission, “because that is where the balance is.”Linton also recommended then, that the legislation be structured so as to give protection to whistle blowers.UWP President Isaac Baptiste told DNO that the party took the position, at that time, not to participate in the Commission because they were unhappy with the changes that had been made to the law.“As a sign of protest, we did not nominate someone on the Commission but seeing that it continued, this time we nominated someone,” Baptiste said.We tried but were unable to reach UWP political leader Lennox Linton, for further comment.An amendment to section four of the Act which now makes it possible for some one other than an attorney-at-law, such as a Chartered Accountant “or a person who has held high administrative, managerial or executive office in the public, private or social sector,” paved the way for a retired public officer like Hyacinth to become Chairman of the Integrity Commission.The mission of The Integrity Commission is to “promote integrity in governance by providing effective oversight of the administration of public functions in order to encourage transparency in transactions, and maintain legal compliance by persons in public life and other public officials so that public institutions will be free of corruption, and so that the highest standards of honesty, equity and fairness will be observed in the use of public resources and in the distribution of benefits for the welfare of the people of our nation.”
HUSD celebrates success by naming Budenholzer Court By Toni Gibbons The name “Budenholzer Court” is slated to become part of the Munoz Gym and the ongoing athletic legacy at Holbrook High School (HHS) as a result of a vote bySubscribe or log in to read the rest of this content. Bottom Ad February 6, 2019
April 2, 2019 Photo by Toni Gibbons Navajo County Assessor Cammy Darris gave her budget presentation at the Board of Supervisors meeting. Photo by Toni Gibbons Navajo County Treasurer Debra Kester updated the Board of Supervisors as toSubscribe or log in to read the rest of this content. Bottom Ad Staff shortages and funding cuts affecting public services